Dianabol Toxicity

Dianabol Toxicity: The Facts, Reviews & Experts Studies on D-bol Hepatoxicity on Liver

Vital INTRO: What really is Dianabol Toxicity? Is it as dangerous or overrated as some guys claims? This article answer several questions, plus clinical studies about Dianabol hepatotoxic, reviews to guide your decision before & during Dbol cycle for bodybuilding…

Brief Overview

Is Dianabol ToxicDianabol, which is also known as Dbol, is the widely accepted commercial name of Methandrostenolone, one of the first oral steroids ever made.

For decades, bodybuilders have continued to use this oral steroid to build muscles, kick-start gains, and promote other male characteristics fueled by testosterone.

But despite the great bulking results achievable with this steroid, the safety of using Dianabol has been the focus of many discussions in health and fitness circles.

Dbol is known to deliver fast gains in strength and lean mass, but it’s also claimed to be hepatotoxic (toxic to the liver).

So, what exactly does this mean for those who are interested in using Dianabol for bodybuilding purposes?

This guide will provide more details regarding the steroid’s toxicity, and users’ reviews, expert studies and scientific facts will be discussed as well in order to separate fact from fiction.

Click here to read a life-changing personal review – how this guy used DBAL to gain mass without toxic effects

What Exactly Is Dbol Hepatotoxicity?

To decipher what Dianabol heatotoxicity actually means, it’s necessary to get the facts on Dbol right – especially on how it interacts with the body.

Unlike injectable hormones, oral steroids like Dianabol must pass through the gastrointestinal system.

Before reaching the blood stream, these steroids travel through the liver where they face the threat of being broken down and filtered out as waste.

Since oral steroids can be metabolized by the liver, thus rendering them ineffective, researchers have found a way to make them more orally bio-available.

By altering the molecular structure of Dianabol at the 17th carbon position with the addition of a methyl or ethyl group, the steroid is capable of surviving its first pass through the liver and into the blood stream without being eliminated. Due to this unique property, D-bol is often referred to as a 17-aa (alpha-alkylated) steroid.

What makes Dianabol hepatotoxic is the fact that its molecular structure contains a strong bond that cannot be easily broken down in the liver.

This in turn causes the liver to work extra hard, which is a process that can be harmful over a prolonged period of time.

In an attempt to break the 17-aa bond of Dianabol molecules, the liver produces additional enzymes such as ALT and AST, explaining why liver values for these enzymes are usually elevated above the normal range in lab test results for bodybuilders who use oral steroids.

Increased liver activity can be detrimental in a number of ways. For instance, the liver may become overwhelmed as it tries to work harder and break down resilient compounds like Dianabol.

A stressed liver also produces 17-glucuronides, which are toxic metabolites responsible for causing most hepatic health problems.

In addition, 17aa-steroids can stress the liver to the point where it’s unable to produce bile. This often happens when bile sites become saturated in a condition known as Choleostasis.

When any of the reasons explained above impair the liver, the organ’s ability to process toxins suffers.

As toxins buildup, it leads to lesions on the liver along with other damage to hepatic cells and tissues. In the worst case scenarios, excessive use of oral steroids for long periods of time can lead to liver failure.


Is Dbol Toxicity Overrated?

Since Dianabol is a 17-aa steroid, it has been said for years that it will eventually ruin the function of the liver if abused.

This is why you’ll always come across advice passed on over the years that states things like:“D-bol should never be run for more than 6 weeks,” “Don’t combine oral steroids in one stack,” “Never go beyond 50mg per day,” and so forth. But is there any actual truth to these fear-mongering claims or is D-bol toxicity simply overrated?

Well, there are divergent opinions about this issue. Some bodybuilders claim that D-bol raises liver values to a point of concern after being used for just a few weeks.

Other people disagree that this could be of any harm citing that famous power lifters in years past had used D-bol for extended periods and never ran into any problems.

A case in point is Arnold Schwarzenegger, one of the most famous bodybuilders of all time who claimed to have used Dianabol for up to 12 weeks with no PCT.

Many people love citing Arnold as the perfect example of why Dianabol toxicity has been blown out of proportion.

There have also been reviews from a set of bodybuilders who all claim to have supplemented with Dianabol on cycles that lasted 8 to 12 weeks, and experienced no ill effects at all.

But then again, negative testimonies regarding Dianabol are not unheard of either, and so the debate goes on.

Many of the comments you’ll read on message boards and online forums are from people merely stating their opinions. It can therefore be difficult for a first time user to know who’s right and who’s wrong.

However, whether Dianabol toxicity is overrated or not depends on a number of factors. For example, how long of a cycle are we talking about and what dose are you considering using?

Factors such as alcohol consumption and use of additional oral steroids also tend to increase risk of liver problems when using Dianabol.

Sometimes risk of liver toxicity can be blown out of proportion especially when Dianabol is passed off as nothing but toxic even at a low dose.

But is there scientific research to back this up? Let’s have a look at some of the studies that have been done on D-bol and its effects on the liver.

Scientific Studies on Dbol and Liver Function

Although Dianabol has been around for a long time, only a few studies about how Dianabol affects the liver had been conducted on humans.

Much of this has to do with the fact that most health governing bodies are usually reluctant to approve drug testing on humans.

But as we wait for health bodies to give the green light for human testing, several anecdotal studies as well as case reports that link Dianabol to liver problems have already been conducted and the results published.

One of the oldest case studies is a 1968 one titled the “Effects of Methandrostenolone on blood lipids and liver function tests” [1]. (See link at the bottom)

In this study, eighteen males in a hospital for the chronically ill took part in the 9-week double-blind test. Some of the test subjects showed increased levels of SGPT values, although these returned to normal despite continued therapy.

Quite a few accounts of liver related complications due to Dianabol use have also been reported over the years.

For instance, a 1994 case study reports of a 38-yearold male who developed Cholestatic jaundice and pruritus due to intake of Dianabol [2]. (See link at the bottom)

And in a 1999 report, a 28-year old bodybuilder was admitted to hospital for jaundice after having supplemented on high doses of anabolic steroids (10 to 50mg Metandienone/Methandrostenolone and 50mg injections Stanozolol) [3]. (See link at the bottom)

While the use of those steroids was discontinued after admission, the patient’s condition got repeatedly got worse, resulting in severe Cholestasis and renal failure.

In a more recent 2011 case report, a 50-yearold man developed Cholestatic jaundice along with acute pancreatitis and kidney injury due to recreational use of Methandrostenolone (Dianabol) [4]. (See link at the bottom)

Interestingly, the patient in this report was only on a 20 to 30mg of Dianabol dosage per day over an 8-week period.

The report mentioned intermittent to occasional heavy alcohol consumption on weekends, which perhaps explains why the patient developed liver problems.


Best Safety Practices When Using Dianabol

Judging by the studies and reports that have been published, there’s no doubt that Dianabol can cause liver related problems.

Some of the case reports indicate that the risk of liver toxicity increases if users take Dianabol while drinking alcohol.

Consequently, it’s important to avoid drinking when using oral anabolic compounds. Alcohol causes inflammation and hardening of hepatic cells and tissues – so imagine what it can do to the liver when combined with Dianabol.

For novice bodybuilders who still wish to use Dianabol in their first cycle, it’s best to start slow. A Dbol only cycle of 6 weeks maximum or 4 at the very least has been reported to be one of the safest ways to kick-start gains.

It’s also recommended to add testosterone in the cycle since D-bol tends to suppress natural production of this hormone in the body.

A simple Test + Dbol stack is easy to administer and it will be easier to pinpoint the root cause of problems, which would otherwise have been difficult if a beginner were to add more steroids to the cycle.

Individual preferences on expected gains matter, but for most healthy adults, 20 to 40mg of Dianabol is a safe dose that can deliver impressive results.

To be on the extra safe side, just start with a low dose and see how your body reacts before increasing your intake.

You’ll never know if you’ll fall into the Arnold Schwazzeneggar camp or be the next guy who ends up with renal failure if you don’t start off on a small dosage and listen to how your body reacts.

  1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1923870/
  2. http://www.ncbi.nlm.nih.gov/pubmed/12369223
  3. http://www.ncbi.nlm.nih.gov/pubmed/10506840
  4. http://www.ncbi.nlm.nih.gov/pubmed/21470406
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